Established in 2008, Beijing Hongrun Baoshun Technology Co., Ltd. took root in the Science and Technology Innovation Area of the China (Beijing) Pilot Free Trade Zone. Through consistent innovation and adherence to extreme industrial standards, we have evolved into a modern high-tech enterprise integrating research and development, production, and global sales.
Today, our brand stands out as a distinguished recipient of dual certifications as a national "High-tech Enterprise" and a "Zhongguancun High-tech Enterprise." We dedicatedly serve bio-pharmaceutical, laboratory research, and industrial fermentation markets worldwide with clean, reliable animal-free and animal-derived nutrients.
Autolysed Yeast Extract represents a premier animal-free organic nitrogen source widely utilized in modern bioprocesses. Derived from primary cultured Saccharomyces cerevisiae, the production process utilizes the yeast cell's endogenous enzymes (such as proteases, nucleases, and glucanases) to break down its own complex proteins, nucleic acids, and cell wall polysaccharides.
Unlike acid-hydrolyzed proteins, which strip vital growth factors, autolysis is a controlled enzymatic digestion. Under optimized temperature (typically 50°C - 55°C) and pH conditions, the cell membranes are permeabilized, activating intracellular proteases. This yields a rich cocktail of free amino acids, peptides, vitamins, and minerals.
AYE is rich in B-complex vitamins (Thiamine, Riboflavin, Niacin, Pantothenic acid), vital trace elements (Zinc, Magnesium, Iron), and key nucleotides (IMP and GMP) which serve as metabolic precursors. Crucially, the nitrogen is highly bioavailable, consisting of balanced free amino acids and small chain peptides.
Using our wholesale autolysed yeast extract ensures reduced lag phases in bacterial culture, accelerated cell density accumulation, and optimized target metabolite expression. It serves as the ultimate animal-component-free (ACF) compound, mitigating risks of transmissible spongiform encephalopathies (TSE/BSE).
In 2018, Hongrun Baoshun upgraded its strategic manufacturing layout by expanding production footprint to the Qili Industrial Park in Langzhong, Sichuan. Leveraging advanced automation, the combined floor area of Phase I and Phase II factories exceeds 40,000 square meters, supported by a state-of-the-art warehousing and cold-chain storage setup of 20,000 square meters.
With over 100 highly trained employees and automated process lines, we run completely separated production pathways for animal-derived and plant-derived raw materials. This eliminates any risk of cross-contamination and allows us to yield large batch sizes, complete customizable specifications, and stable product quality.
Our corporate strength is amplified by our five dedicated subsidiaries working in perfect unison to cover everything from biological raw material procurement to custom media formulations and logistics.
R&D & Science Innovation Hub
Large-scale Biotech Fermentation
Specialized Industrial Mediums
Quality Control & Audit Support
Supply Chain & Global Logistics
Our wholesale autolysed yeast extract, peptone, and tryptone powders are formulated to meet the challenging nutritional needs of various micro-organisms and mammalian cell structures across different fields.
Key nitrogen components for culturing recombinant proteins, monoclonal antibodies (mAbs), and viral/bacterial vaccines. Low endotoxin levels and ultra-high solubility guarantee stability during downstream purification.
Powers the production of organic acids, therapeutic enzymes, biological plastics (PHA), and high-yield amino acid fermentations. Excellent batch-to-batch consistency ensures stable production processes.
Provides essential growth factors and nucleotides to support the rapid growth of sensitive strains such as Lactobacillus, Bifidobacterium, and other beneficial live microbes.
Every cell line and microbial strain has unique nutritional preferences. At Hongrun Baoshun, we do not believe in one-size-fits-all. We work alongside global procurement directors and R&D formulation specialists to customize and optimize bulk organic nitrogen supplies.
We provide free samples up to 500g per product (excluding shipping fees) to help you run initial trials and validation studies in your R&D labs.
We adjust crucial parameters including molecular weight distribution of peptides, total/amino nitrogen ratios, salt content, and specific pH levels.
Once validated, we lock in your specific product codes for full-scale commercial manufacturing with guaranteed delivery times through our logistics network.
We strictly implement a Quality Management System that matches international regulatory standards. Our philosophy, "no substandard products leave the factory," ensures absolute reliability for global bioprocess scaling.
Our ISO certified framework monitors all critical quality parameters from raw materials to final packaging. Every batch undergoes strict chromatography, microbiological screening, and chemical analysis.
Our dedicated animal-free yeast autolysis process lines are MUI Halal compliant, allowing you to formulation products targeting global markets without regional regulatory barriers.
Our dedicated, multilingual customer support team handles requests globally. We assist throughout the registration, customs documentation, and post-shipment auditing phases.
Consistent yield is the primary metric for fermentation processes. Minor variances in organic nitrogen compositions can result in significant drops in target proteins. Hongrun Baoshun's advanced industrial autolysis line utilizes continuous enzyme-inactivation steps to secure stable chemical specifications.
Our production ensures that the Amino Nitrogen (AN) to Total Nitrogen (TN) ratio is kept in an optimized sweet spot. This guarantees the microbes receive both immediate free amino acid nutrients and small peptides that stimulate cellular metabolism over longer cycles.
Through filtration steps, we maintain low turbidity values in reconstituted media. This avoids downstream filtration blockages, speeds up harvest protocols, and helps simplify purification steps for biopharmaceuticals.
Autolysed yeast extract is produced using the cell's own internal enzymes to digest proteins and nutrients. Hydrolyzed yeast extract is typically made by adding external acids or commercial enzymes. Autolysis offers a gentler extraction process, yielding a richer spectrum of natural B-complex vitamins, nucleotides, and trace elements, making it superior for complex micro-organism growth.
At our Sichuan manufacturing base, animal-derived production lines and plant-derived production lines are housed in completely separate buildings. We utilize dedicated air handling systems, storage warehouses, and independent process equipment to guarantee zero cross-contamination.
Hongrun Baoshun products are backed by ISO 9001:2015 quality management system certification. Our yeast extract lines also hold MUI Halal certification, ensuring suitability for global projects with strict religious and dietary requirements.
Yes, we support extensive customization options. We can adjust nutritional attributes (molecular weight distribution, amino/total nitrogen, salt levels) and offer packaging ranges from 1kg trial bags to 25kg drums and bulk industrial bags.
Standard samples (up to 500g) are dispatched within 2-3 business days. Custom formulations require detailed technical alignment, but are usually produced and shipped within 2-3 weeks.
Hongrun Baoshun